[sheet: Budget Summary]

[sheet: Budget Summary]
Line Item # | Budget Category | Description | Unit Cost | Quantity / Units | Subtotal | % of Total Budget
1 | Per-Patient Site Fees | Screen-to-completion per-patient payments across all 38 Veridian Network sites (milestone-based) | $52,000 | 1,200 subjects | $62,400,000 | 78.00%
2 | Site Start-Up Fees | One-time site activation and start-up costs per participating site | $75,000 | 38 sites | $2,850,000 | 3.56%
3 | Annual Site Maintenance Fees | Annual operational maintenance fee per site, averaged over 3.5 years | $40,000/site/year | 38 sites × 3.5 years | $5,320,000 | 6.65%
4 | Investigator Grants | Academic publication support and investigator research grants | Lump sum | — | $1,500,000 | 1.88%
5 | Network Coordination / Administrative Fee | Quarterly administrative fee to Veridian central for network coordination | $300,000/quarter | 14 quarters | $4,200,000 | 5.25%
6 | Technology / EDC Integration Costs | Fixed cost for integration with Pinnacle Data Solutions, Inc. eClinical/EDC platform | Fixed | — | $1,230,000 | 1.54%
7 | Contingency / Change Order Reserve | Reserve for unanticipated costs, change orders, and protocol amendments | Fixed | — | $2,500,000 | 3.13%
TOTAL BUDGET | $80,000,000 | 100.00%
[sheet: Per-Patient Milestone Schedule]
Milestone # | Milestone Description | Milestone Trigger Event | Payment Per Subject | % of Per-Patient Fee | Estimated Subjects | Estimated Total Payment at Milestone
1 | Randomization | Subject randomized per Protocol PPC-4871-III | $13,000 | 25% | 1,200 | $15,600,000
2 | Week 12 Assessment | Completion of Week 12 tumor assessment visit per Protocol | $13,000 | 25% | 1,200 | $15,600,000
3 | Week 24 Assessment | Completion of Week 24 tumor assessment visit per Protocol | $13,000 | 25% | 1,200 | $15,600,000
4 | Study Completion / Final Visit | Completion of end-of-treatment or final follow-up visit per Protocol | $13,000 | 25% | 1,200 | $15,600,000
TOTAL PER-PATIENT FEES | $52,000 | 100% | 1,200 | $62,400,000
[sheet: Start-Up Fee Schedule]
Installment # | Installment Description | Trigger Event | Amount Per Site | Number of Sites | Total
1 | First Installment — Site Activation | Upon site activation (regulatory and IRB approval confirmed, site initiation visit completed) | $37,500 | 38 | $1,425,000
2 | Second Installment — First Patient Enrolled | Upon enrollment (randomization) of first subject at the site | $37,500 | 38 | $1,425,000
TOTAL START-UP FEES | $75,000 | 38 | $2,850,000
[sheet: Site Maintenance Fee Schedule]
Year | Period | Annual Fee Per Site | Number of Active Sites | Annual Total | Payment Timing
Year 1 | Aug 2023 – Jul 2024 | $40,000 | 38 | $1,520,000 | Paid annually in advance on each site-activation anniversary
Year 2 | Aug 2024 – Jul 2025 | $40,000 | 38 | $1,520,000 | Paid annually in advance on each site-activation anniversary
Year 3 | Aug 2025 – Jul 2026 | $40,000 | 38 | $1,520,000 | Paid annually in advance on each site-activation anniversary
Year 4 (partial — avg 0.5 yr) | Aug 2026 – Jan 2027 (est.) | $20,000 (prorated) | 38 | $760,000 | Prorated for partial year; paid in advance
TOTAL SITE MAINTENANCE FEES | $5,320,000
[sheet: Network Coordination Fee Schedu]
Quarter # | Quarter Period | Quarterly Payment | Cumulative Paid
Q1 | Jul 2023 – Sep 2023 | $300,000 | $300,000
Q2 | Oct 2023 – Dec 2023 | $300,000 | $600,000
Q3 | Jan 2024 – Mar 2024 | $300,000 | $900,000
Q4 | Apr 2024 – Jun 2024 | $300,000 | $1,200,000
Q5 | Jul 2024 – Sep 2024 | $300,000 | $1,500,000
Q6 | Oct 2024 – Dec 2024 | $300,000 | $1,800,000
Q7 | Jan 2025 – Mar 2025 | $300,000 | $2,100,000
Q8 | Apr 2025 – Jun 2025 | $300,000 | $2,400,000
Q9 | Jul 2025 – Sep 2025 | $300,000 | $2,700,000
Q10 | Oct 2025 – Dec 2025 | $300,000 | $3,000,000
Q11 | Jan 2026 – Mar 2026 | $300,000 | $3,300,000
Q12 | Apr 2026 – Jun 2026 | $300,000 | $3,600,000
Q13 | Jul 2026 – Sep 2026 | $300,000 | $3,900,000
Q14 | Oct 2026 – Dec 2026 | $300,000 | $4,200,000
TOTAL NETWORK COORDINATION FEE | $4,200,000 | $4,200,000
[sheet: Other Costs]
Line Item # | Budget Category | Description | Amount | Payment Trigger / Timing | Payee
1 | Investigator Grants | Academic publication support and investigator research grants for peer-reviewed publications arising from Protocol PPC-4871-III | $1,500,000 | Disbursed upon acceptance of manuscripts for publication in peer-reviewed journals | Individual investigators at Veridian Network sites
2 | Technology / EDC Integration Costs | Fixed cost for integration of Pinnacle Data Solutions, Inc. eClinical/EDC platform with Veridian Network site systems for electronic data capture | $1,230,000 | Invoiced upon completion of EDC system build, testing, and validation prior to site activation | Pinnacle Data Solutions, Inc. (via Penterra)
3 | Contingency / Change Order Reserve | Reserve for unanticipated costs, protocol amendments, additional site activations, and change orders during the life of the CLARION trial | $2,500,000 | Released upon mutual written approval of change orders per Section [X] of the MCTA | As applicable per change order
TOTAL OTHER COSTS | $5,230,000